Research progression of the relationship between integrin α2β1 and drug-induced gingival overgrowth / 华西口腔医学杂志

Drug-induced gingival overgrowth (DIGO) is characterized by fibrous gingival hyperplasia and increased gingival volume. DIGO is histologically associated with proliferation of cells and deposition of extracellular matrices, particularly collagen. Integrin α2β1 is related to collagen phagocytosis and involved in the occurrence and progression of DIGO. This paper reviews the progress of research on the relationship between integrin α2β1 and DIGO.

Comparison between Laser, Electrocautery and Scalpel in the Treatment of Drug-Induced Gingival Overgrowth: A Case Report.

Drug-induced gingival overgrowth (DIGO) is a well-recognized, unwanted side-effect associated with three major drug groups - anticonvulsants, immunosuppressants and the calcium channel blockers. The prevalence of this unwanted side effect is 25-80% and is also dependent on other factors such as type of drug, dosage, duration of treatment, genetic predisposition, and patient’s oral hygiene maintenance. Three different treatment modalities viz., scalpel, laser, and electrocautery can be used for treating DIGO. Each method carries its own merits and demerits. In the present case report, these three different treatment modalities are used in the same patient in order to compare their handling properties and effect on initial wound healing. Though scalpel remains to be gold standard treatment, use of laser finds some more advantages over the electrocautery for treatment of DIGO.

Hiperplasia gengival medicamentosa: parte I / Drug induced gingival hyperplasia: part I

INTRODUÇÃO: A hiperplasia gengival pode ser causada por alguns medicamentos, entre os quais a fenitoína. Torna-se importante a prevenção, o diagnóstico precoce e o seguimento de pessoas com epilepsia por profissional da área odontológica. OBJETIVO: O presente artigo tem o propósito de discutir os aspectos etiológicos, clínicos e terapêuticos da hiperplasia gengival medicamentosa. METODOLOGIA: Revisão da literatura. RESULTADOS: A necessidade de aliar o tratamento odontológico ao tratamento medicamentoso é enfatizada como forma de prevenir e/ou minimizar a hiperplasia gengival medicamentosa conseqüente à ação farmacológica de algumas drogas e fatores irritantes localizados nos tecidos dentais e periodontais.

INTRODUCTION: Gingival hyperplasia may be caused by some drugs including phenytoin. There are very important factors in this area, including prevention, early diagnosis, and follow-up of people with epilepsy by an specialist in odontological area. OBJECTIVE: The aim of this paper is to discuss the etiology, clinical and therapeutic aspects of drug induced gingival hyperplasia. METHODOLOGY: Literature review. RESULTS: The need to combine dental and drug treatment is emphasized as a way to prevent and/or minimize drug induced gingival hyperplasia due to pharmacological action of some drugs, as well as, local dental and periodontal irritants.